PEG–Peptide Conjugates
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چکیده
منابع مشابه
Conjugates toward medicines
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متن کاملHamming distance for conjugates
Let x, y be strings of equal length. The Hamming distance h(x, y) between x and y is the number of positions in which x and y differ. If x is a cyclic shift of y, we say x and y are conjugates. We consider f(x, y), the Hamming distance between the conjugates xy and yx. Over a binary alphabet f(x, y) is always even, and must satisfy a further technical condition. By contrast, over an alphabet of...
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Glutathione monolayer-protected gold clusters were reacted by place exchange with 19- or 20-residue thiolated oligonucleotides. The resulting DNA/nanoparticle conjugates could be separated on the basis of the number of bound oligonucleotides by gel electrophoresis and assembled with one another by DNA-DNA hybridization. This approach overcomes previous limitations of DNA/nanoparticle synthesis ...
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Enzymes, fluorochromes and other marker molecules are commonly used in a variety of applications to provide specific detection signals. To this aim, they may be conjugated to antibodies, avidin, protein A or G and other proteins in many ways. Fundamental work on chemical modification of proteins and antibody labelings has already been done long before AH COONS and co-workers employed those tech...
متن کاملPeptide-LNA oligonucleotide conjugates.
Although peptide-oligonucleotide conjugates (POCs) are well-known for nucleic acids delivery and therapy, reports on internal attachment of peptides to oligonucleotides are limited in number. To develop a convenient route for preparation of internally labeled POCs with improved biomedical properties, peptides were introduced into oligonucleotides via a 2'-alkyne-2'-amino-LNA scaffold. Derivativ...
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ژورنال
عنوان ژورنال: Biomacromolecules
سال: 2014
ISSN: 1525-7797,1526-4602
DOI: 10.1021/bm500246w